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Increased endoneurial fluid pressure in galactose neuropathy
Author(s) -
Myers Robert R.,
Costello Michael L.,
Powell Henry C.
Publication year - 1979
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880020410
Subject(s) - edema , pathogenesis , peripheral neuropathy , medicine , galactose , polyneuropathy , endocrinology , diabetes mellitus , anesthesia , chemistry , biochemistry
Edema and increased endoneurial fluid pressure developed in peripheral nerves of rats that received a diet containing 40% galactose during a study of the role of sugar alcohols in producing neuropathy. Fluid pressure was elevated starting in the third month and progressed to a fivefold increase over control values by the fifth month. Microscopic examination confirmed the presence of edema as predicted by the sorbitol theory, which is often invoked to explain the pathogenesis of diabetic neuropathy.