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Prednisone‐neostigmine interactions at cholinergic junctions
Author(s) -
Noble Mark David,
Peacock John Hollis,
Lacher Jeffrey Allen,
Hofmann William Ward
Publication year - 1979
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880020210
Subject(s) - neostigmine , prednisone , diaphragm (acoustics) , myasthenia gravis , acetylcholinesterase , cholinergic , medicine , neuromuscular junction , corticosteroid , chemistry , endocrinology , anesthesia , pharmacology , psychology , neuroscience , enzyme , biochemistry , physics , acoustics , loudspeaker
The effect of corticosteroid (prednisone) and/or chronic anticholinesterase (neostigmine) treatment on α‐bungarotoxin binding was examined in the diaphragms of male rats. In endplate regions of the diaphragm, prednisone treatment had no effect on the density of toxin binding sites, either when given alone or when administered in conjunction with neostigmine, while neostigmine was observed to reduce specific binding to less than half after one week.