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Delayed functional disability in dystrophic chickens receiving chemotherapy
Author(s) -
Hudecki Michael S.,
Pollina Catherine M.,
Bhargava Arvind K.,
Hudecki Rajmohini S.,
Heffner Reid R.
Publication year - 1979
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880020109
Subject(s) - methysergide , cyproheptadine , medicine , chemotherapy , microgram , creatine kinase , drug , penicillamine , endocrinology , serotonin , pharmacology , biology , in vitro , biochemistry , receptor
Abstract Line 413 early‐onset, genetically homozygous dystrophic chickens were given twice‐daily intraperitoneal injections of the antiserotoninergic drug cinanserin, alone or in combination with methysergide. Other trials consisted of penicillamine treatment in combination with either methysergide or cyproheptadine. Chemotherapy significantly prolonged the righting ability of treated dystrophic chickens, as measured by a periodic standardized fliptest procedure. Plasma creatine kinase activities were not affected by any of the various drug treatments. However, the blood serotonin levels of the dystrophic chickens (grand mean 1.47 μg serotonin/ml blood) were found to be significantly higher (p<0.001) than those in the corresponding normal chickens (0.99 μg/ml). This finding may partially account for the antiserotoninergic drug enhancement in righting ability that was demonstrated in the drug‐treated dystrophic chickens.