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Acute muscle necrosis after chronic overdosage of phenformin and fenfluramine
Author(s) -
Palmucci L.,
Bertolotto A.,
Schiffer D.
Publication year - 1978
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880010311
Subject(s) - myoglobinuria , phenformin , medicine , necrosis , fenfluramine , myoglobin , etiology , endocrinology , rhabdomyolysis , chemistry , receptor , biochemistry , metformin , insulin , serotonin
A case of acute muscle necrosis with probable myoglobinuria is presented. The patient had been taking excessive doses of phenformin and fenfluramine, and a toxic etiology is suggested. Muscle necrosis is tentatively attributed either to the combined effect of these drugs on some underlying biochemical abnormality of muscle or to a defect of oxygen utilization secondary to myoglobin alterations.