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Recovery of foot drop in chronic inflammatory demyelinating polyneuropathy (CIDP)
Author(s) -
Weerasinghe Dinushi,
Veerapandiyan Aravindhan,
Stanton Michael,
Herrmann David N.,
Akmyradov Chary,
Logigian Eric
Publication year - 2021
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.27253
Subject(s) - chronic inflammatory demyelinating polyneuropathy , medicine , ankle dorsiflexion , foot drop , ankle , muscle power , presentation (obstetrics) , polyneuropathy , foot (prosody) , physical medicine and rehabilitation , surgery , physical therapy , immunology , antibody , linguistics , philosophy
/Aims Foot drop is common in chronic inflammatory demyelinating polyneuropathy (CIDP), but its prognosis is uncertain. Methods CIDP patients with less than anti‐gravity strength (<3/5 power) of ankle dorsiflexion (ADF) on Medical Research Council manual muscle testing on presentation at our center were identified by retrospective review. After initiation of standard treatment, ADF power was serially tabulated, and predictors of recovery were determined. Results Of the 27 identified patients, ADF power at presentation was <3/5 in 48/54 legs. At 1 y after treatment, ADF power improved to >/= 3/5 in 17/27 patients in one (N = 6) or both (N = 11) legs. On multi‐variate analysis, predictors of recovery of ADF power were tibialis anterior compound muscle action potential amplitude at presentation, shorter disease duration, and female gender. Discussion Foot drop improves to anti‐gravity power in most treated CIDP patients depending in part on the severity of fibular motor axon loss at onset of treatment.