Premium
Chronic idiopathic axonal polyneuropathy: Electrophysiological progression and human leukocyte antigen associations
Author(s) -
Zis Panagiotis,
Sarrigiannis Ptolemaios G.,
Artemiadis Artemios,
Skarlatou Vasiliki,
Hadjivassiliou Marios
Publication year - 2021
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.27164
Subject(s) - electrophysiology , medicine , polyneuropathy , pathogenesis , human leukocyte antigen , immunology , antigen
Background We aimed to describe the electrophysiological progression rate of chronic idiopathic axonal polyneuropathy (CIAP) and look into the potential role of human leukocyte antigen (HLA) genetic susceptibility in its development. Methods We recruited 57 patients with CIAP (mean age at diagnosis 67, mean follow‐up 7 years). The assessments included clinical and electrophysiological data and HLA‐DQ genotyping. Results The DQA1*05 allele was found more frequently in patients than in healthy controls (odds ratio, 1.96, P = .011). In patients with length‐dependent CIAP, a linear effect of time on the electrophysiological findings was found in the superficial radial (3.2% mean annual decrement, P < .001), sural (4.7% mean annual decrement, P = .002) and tibial nerve (6.1% mean annual decrement, P = .007) amplitudes, independently from age or gender. Conclusions Patients with length‐dependent CIAP, show a linear progression over time. Interesting associations of HLA‐DQA1*05 allele with length‐dependent CIAP and non‐DQ2/DQ8 with idiopathic sensory ganglionopathy were found. These merit further investigation in larger cohorts and may suggest a role of the immune system in the pathogenesis of CIAP.