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Regenerative peripheral nerve interface free muscle graft mass and function
Author(s) -
Hu Yaxi,
Ursu Daniel C.,
Sohasky Racquel A.,
Sando Ian C.,
Ambani Shoshana L. W.,
French Zachary P.,
Mays Elizabeth A.,
Nedic Andrej,
Moon Jana D.,
Kung Theodore A.,
Cederna Paul S.,
Kemp Stephen W. P.,
Urbanchek Melanie G.
Publication year - 2021
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.27138
Subject(s) - isometric exercise , skeletal muscle , peripheral , anatomy , medicine , regeneration (biology) , peripheral nerve , myocyte , biomedical engineering , chemistry , biology , microbiology and biotechnology
Abstract Background Regenerative peripheral nerve interfaces (RPNIs) transduce neural signals to provide high‐fidelity control of neuroprosthetic devices. Traditionally, rat RPNIs are constructed with ~150 mg of free skeletal muscle grafts. It is unknown whether larger free muscle grafts allow RPNIs to transduce greater signal. Methods RPNIs were constructed by securing skeletal muscle grafts of various masses (150, 300, 600, or 1200 mg) to the divided peroneal nerve. In the control group, the peroneal nerve was transected without repair. Endpoint assessments were conducted 3 mo postoperatively. Results Compound muscle action potentials (CMAPs), maximum tetanic isometric force, and specific muscle force were significantly higher for both the 150 and 300 mg RPNI groups compared to the 600 and 1200 mg RPNIs. Larger RPNI muscle groups contained central areas lacking regenerated muscle fibers. Conclusions Electrical signaling and tissue viability are optimal in smaller as opposed to larger RPNI constructs in a rat model.