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Premium Challenges in diagnosing coexisting ocular myasthenia gravis and thyroid eye disease
Claytor Benjamin,
Li Yuebing
Publication year2021
Publication title
muscle and nerve
Resource typeJournals
PublisherJohn Wiley & Sons
Abstract Ocular myasthenia gravis (OMG) and thyroid eye disease are two autoimmune conditions that have several overlapping clinical features, and these coexist with a small but not insignificant frequency. Segregating these diagnoses is typically straightforward, but, when the two diseases co‐occur in the same individual, making a diagnosis of OMG can be very challenging. In this review we address what is known about the coexistence of OMG and thyroid eye disease and we highlight the clinical features that are suggestive of overlapping conditions. We also describe the major testing approaches used in the diagnosis of these two entities, with special emphasis on the potential shortcomings of individual tests in patients with overlapping disease. In patients with thyroid eye disease, securing a diagnosis of OMG may not be possible on the basis of a single positive test. A multimodal approach using clinical, serologic, imaging, and electrodiagnostic data, is typically required.
Subject(s)dermatology , disease , eye disease , medicine , myasthenia gravis , neuromuscular disease , ocular myasthenia , ophthalmology , pathology , pediatrics , thyroid , thyroid disease
SCImago Journal Rank1.025

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