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Ultrasound can differentiate inclusion body myositis from disease mimics
Author(s) -
Leeuwenberg Kristofoor E.,
Alfen Nens,
ChristopherStine Lisa,
Paik Julie J.,
Tiniakou Eleni,
Mecoli Christopher,
Doorduin Jonne,
Saris Christiaan G.J.,
Albayda Jemima
Publication year - 2020
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.26875
Subject(s) - inclusion body myositis , polymyositis , medicine , dermatomyositis , myositis , echogenicity , neuromuscular disease , muscular dystrophy , ultrasound , pathology , physical medicine and rehabilitation , disease , radiology
The diagnosis of inclusion body myositis (IBM) can be challenging, and its presentation can be confused with other forms of myositis or neuromuscular disorders. In this study we evaluate the ability of quantitative muscle ultrasound to differentiate between IBM and mimicking diseases. Methods Patients 50 years of age and older were included from two specialty centers. Muscle echogenicity and muscle thickness of four characteristically involved muscles in IBM were measured and compared with polymyositis (PM)/dermatomyositis (DM), other neuromuscular disorders, and healthy controls. Results Echogenicity was higher and muscle thickness generally lower in all four muscles in IBM compared with PM/DM and normal controls. When comparing IBM with the comparator groups, the flexor digitorum profundus was the most discriminative muscle. Discussion Ultrasound appears to be a good test to differentiate established IBM from PM/DM and neuromuscular controls, with value as a diagnostic tool for IBM.