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Conference report on contractures in musculoskeletal and neurological conditions
Author(s) -
Nuckolls Glen H.,
Kinnett Kathi,
Dayanidhi Sudarshan,
Domenighetti Andrea A.,
Duong Tina,
Hathout Yetrib,
Lawlor Michael W.,
Lee Sabrina S. M.,
Magnusson S. Peter,
McDonald Craig M.,
McNally Elizabeth M.,
Miller Natalie F.,
Olwin Bradley B.,
Raghavan Preeti,
Roberts Thomas J.,
Rutkove Seward B.,
Sarwark John F.,
Senesac Claudia R.,
Vogel Leslie F.,
Walter Glenn A.,
Willcocks Rebecca J.,
Rymer William Z.,
Lieber Richard L.
Publication year - 2020
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.26845
Subject(s) - muscle contracture , physical medicine and rehabilitation , medicine , physical therapy , surgery
Limb contractures are debilitating complications associated with various muscle and nervous system disorders. This report summarizes presentations at a conference at the Shirley Ryan AbilityLab in Chicago, Illinois, on April 19–20, 2018, involving researchers and physicians from diverse disciplines who convened to discuss current clinical and preclinical understanding of contractures in Duchenne muscular dystrophy, stroke, cerebral palsy, and other conditions. Presenters described changes in muscle architecture, activation, extracellular matrix, satellite cells, and muscle fiber sarcomeric structure that accompany or predispose muscles to contracture. Participants identified ongoing and future research directions that may lead to understanding of the intersecting factors that trigger contractures. These include additional studies of changes in muscle, tendon, joint, and neuronal tissues during contracture development with imaging, molecular, and physiologic approaches. Participants identified the requirement for improved biomarkers and outcome measures to identify patients likely to develop contractures and to accurately measure efficacy of treatments currently available and under development.