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Primary lateral sclerosis (PLS) functional rating scale: PLS‐specific clinimetric scale
Author(s) -
Mitsumoto Hiroshi,
Chiuzan Codruta,
Gilmore Madison,
Zhang Yuan,
Simmons Zachary,
Pagai Sabrina,
Kisanuki Yasushi Y.,
Zinman Lorne,
Jawdat Omar,
Sorenson Eric,
Floeter Mary Kay,
Pioro Erik P.,
Fernandes Filho J. Americo M.,
Heitzman Daragh,
Fournier Christiicole,
Oskarsson Bjorn,
HeimanPatterson Terry,
Maragakis Nicholas,
Joyce Nanette,
Hayat Ghazala,
Nations Sharon,
Scelsa Stephen,
Walk David,
Elman Lauren,
Hupf Jonathan,
McHale Brittany
Publication year - 2020
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.26765
Subject(s) - rating scale , physical therapy , quality of life (healthcare) , construct validity , inter rater reliability , physical medicine and rehabilitation , psychology , activities of daily living , reliability (semiconductor) , medicine , psychometrics , clinical psychology , developmental psychology , power (physics) , physics , quantum mechanics , psychotherapist
Abstract Introduction Our research aim was to develop a novel clinimetric scale sensitive enough to detect disease progression in primary lateral sclerosis (PLS). Methods A prototype of the PLS Functional Rating Scale (PLSFRS) was generated. Seventy‐seven participants with PLS were enrolled and evaluated at 21 sites that comprised the PLSFRS study group. Participants were assessed using the PLSFRS, Neuro‐Quality of Life (QoL), Schwab‐England Activities of Daily Living (ADL), and the Clinical Global Impression of Change scales. Participants completed telephone assessments at 12, 24, and 48 weeks after enrollment. Results The PLSFRS demonstrated internal consistency as well as intrarater, interrater, telephone test‐retest reliability, and construct validity. Significant changes in disease progression were detected at 6 and 12 months; changes measured by the PLSFRS vs the ALSFRS‐R were significantly higher. Discussion The PLSFRS is a valid tool to assess the natural history of PLS in a shorter study period.