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Use of a wearable device to assess sleep and motor function in Duchenne muscular dystrophy
Author(s) -
Siegel Benjamin I.,
Cakmak Ayse,
Reinertsen Erik,
Benoit Macarthur,
Figueroa Janet,
Clifford Gari D.,
Phan Han C.
Publication year - 2020
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.26759
Subject(s) - actigraphy , medicine , ambulatory , duchenne muscular dystrophy , physical therapy , physical medicine and rehabilitation , sleep (system call) , audiology , circadian rhythm , computer science , operating system
Abstract Introduction Rest‐activity disruption is an important feature of Duchenne muscular dystrophy (DMD). We sought to describe sleep impairment and its relationship to quality of life (QOL) and to evaluate associations between rest‐activity, sleep quality, and 6‐minute walk test (6MWT) in DMD. Methods Sleep impairment and its relationship to QOL was assessed by questionnaire in 54 children (33 ambulatory, 21 nonambulatory) with DMD. Rest‐activity characteristics were calculated for 23 of these children (14 ambulatory, nine nonambulatory) by actigraphy. Results Pathologic sleep was reported in 11 (20%) participants and correlated with lower QOL but not with ambulatory status. In ambulatory participants who completed actigraphy, rest‐activity rhythm fragmentation was associated with subjective sleep impairment. Habitual daytime activity level was associated with 6MWT performance. Discussion Children with DMD experience substantial sleep impairment that is related to QOL. Wrist actigraphy may be a parsimonious tool for monitoring both sleep and motor impairment in ambulatory children with DMD.