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Comparative value and determinants of suitability of outcome measures in treated chronic inflammatory demyelinating polyneuropathy
Author(s) -
Rajabally Yusuf A.,
Ghasemi Majid
Publication year - 2020
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.26747
Subject(s) - chronic inflammatory demyelinating polyneuropathy , medicine , polyneuropathy , physical therapy , immunology , antibody
The comparative value and suitability of outcome measures are uncertain in chronic inflammatory demyelinating polyneuropathy (CIDP). Methods We studied 35 patients with CIDP using the Overall Neuropathy Limitation Scale (ONLS), the inflammatory Rasch‐built Overall Disability Scale (I‐RODS), and the Medical Research Council Sum Score (MRCSS). Results Significant associations were determined between initial deficit and ONLS score ( P = .002) and MRCSS improvement ( P = .001) but not I‐RODS score. A strong inverse correlation was observed between disease duration and I‐RODS score( P = .002) but not ONLS/MRCSS improvement. A strong association was observed between age ≤ 40 years and I‐RODS score ( P = .001) but not ONLS/MRCSS improvement. When minimum important differences were used, ONLS and I‐RODS sensitivities were comparable ( P = .19). Discussion Overall Neuropathy Limitation Scale and I‐RODS are equally sensitive in identifying change. Ease of administration, better ability to detect improvement in severe disease, and greater amplitude responses throughout the disease and in older patients favor the ONLS. The I‐RODS appears more useful in early disease/younger patients.