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Membrane property changes in most distal motor axons in chronic inflammatory demyelinating polyneuropathy
Author(s) -
Amino Hiroshi,
Shibuya Kazumoto,
Misawa Sonoko,
Sekiguchi Yukari,
Beppu Minako,
Suichi Tomoki,
Suzuki Yoichi,
Tsuneyama Atsuko,
Kuwabara Satoshi
Publication year - 2020
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.26744
Subject(s) - chronic inflammatory demyelinating polyneuropathy , medicine , motor nerve , wrist , trunk , ulnar nerve , neuromuscular junction , pathophysiology , median nerve , neuroscience , axon , anatomy , pathology , elbow , biology , immunology , antibody , ecology
Distal nerve terminals, where the blood‐nerve barrier is anatomically deficient, are preferentially affected in immune‐mediated neuropathies. Excitability alterations near the motor nerve terminals may be more prominent than the nerve trunk in typical chronic inflammatory demyelinating polyneuropathy (CIDP). Methods In 20 patients with typical CIDP, motor nerve excitability testing was performed at the motor point and wrist of the ulnar nerve, and results were compared with those in 20 healthy persons. Results Chronic inflammatory demyelinating polyneuropathy patients showed greater threshold changes in hyperpolarizing threshold electrotonus at the motor point ( P < .05) but not at the wrist. Strength‐duration time constant did not show significant differences between CIDP and controls at both sites. Discussion Axonal property changes in CIDP are more prominent in distal portions of axons compared with the nerve trunk, presumably due to salient demyelination near the distal nerve terminals. Motor point excitability measurements could elucidate underlying pathophysiology in immune‐mediated neuropathies.