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Endurance exercise leads to beneficial molecular and physiological effects in a mouse model of myotonic dystrophy type 1
Author(s) -
Sharp Lydia,
Cox Diana C.,
Cooper Thomas A.
Publication year - 2019
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.26709
Subject(s) - myotonic dystrophy , endurance training , wasting , medicine , muscular dystrophy , skeletal muscle , endocrinology , myotonia
Myotonic dystrophy type 1 (DM1) is a multisystemic disease caused by expansion of a CTG repeat in the 3' UTR of the Dystrophia Myotonica‐Protein Kinase (DMPK) gene. While multiple organs are affected, more than half of mortality is due to muscle wasting. Methods It is unclear whether endurance exercise provides beneficial effects in DM1. Here, we show that a 10‐week treadmill endurance exercise program leads to beneficial effects in the HSA LR mouse model of DM1. Results Animals that performed treadmill training displayed reduced CUGexp RNA levels, improved splicing abnormalities, an increase in skeletal muscle weight and improved endurance capacity. Discussion These results indicate that endurance exercise does not have adverse effects in HSA LR animals and contributes to beneficial molecular and physiological outcomes.