Premium
Muscle thickness measured by ultrasound is reduced in neuromuscular disorders and correlates with clinical and electrophysiological findings
Author(s) -
Abraham Alon,
Drory Vivian E.,
Fainmesser Yaara,
Algom Avi A.,
Lovblom Leif E.,
Bril Vera
Publication year - 2019
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.26693
Subject(s) - medicine , myopathy , polyneuropathy , neuromuscular disease , electrophysiology , electromyography , lower motor neuron , physical medicine and rehabilitation , prospective cohort study , ultrasound , physical therapy , motor neuron , radiology , disease
Nerve imaging has a limited role in axonal and muscle fiber loss. In this study, we sought to explore the utility of standardized muscle ultrasound (US) assessment in these clinical scenarios. Methods We performed a prospective study from March to August 2018 of patients attending the neuromuscular clinic. All patients underwent clinical evaluation and standardized muscle thickness measurement by US in seven muscles. Results The study cohort consisted of 114 participants, including patients with polyneuropathy, motor neuron disease, and myopathy. The smallest distal muscle thickness was found in patients with polyneuropathy, while the smallest proximal muscle thickness was found in patients with myopathy. Muscle thickness was strongly correlated with muscle strength ( r 2 = 0.62), electrophysiological findings ( r 2 : 0.44‐0.55), and disability score ( r 2 = 0.53). Discussion Standardized muscle thickness measured by US shows diagnostic usefulness in a spectrum of neuromuscular disorders and correlates with clinical and electrophysiological findings.