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Chronic immune sensorimotor polyradiculopathy: Report of a case series
Author(s) -
Thammongkolchai Thananan,
Suhaib Omer,
Termsarasab Pichet,
Li Yuebing,
Katirji Bashar
Publication year - 2019
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.26436
Subject(s) - polyradiculopathy , polyradiculoneuropathy , medicine , nerve root , peripheral , peripheral nervous system , cranial nerves , sural nerve , electromyography , chronic inflammatory demyelinating polyneuropathy , pathology , sensory nerve , sensory system , anatomy , guillain barre syndrome , neuroscience , central nervous system , physical medicine and rehabilitation , immunology , psychology , antibody
Chronic immune sensorimotor polyradiculopathy (CISMP) is a chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) variant affecting both sensory and motor nerve roots without evidence of peripheral nerve demyelination. Methods We report a case series of 9 patients with CISMP, identified from 2 tertiary centers. Clinical, electrodiagnostic, and neuroradiologic features, and treatment responses, were retrospectively reviewed. Results Patients presented with sensorimotor deficits and hypo‐/areflexia, predominantly involving lower extremities. Three had cranial nerve involvement. Electrodiagnostic findings in all patients localized to roots proximal to dorsal root ganglia, without evidence of peripheral nerve demyelination. Cerebrospinal fluid examination revealed an albuminocytologic association. Eight patients exhibited gadolinium enhancement and thickening of multiple spinal nerve roots and/or cranial nerves. All patients demonstrated good responses to immunotherapies. Discussion CISMP is similar to CIDP in many aspects, but lacks typical electrodiagnostic findings of peripheral nerve demyelination. It is important to recognize this unusual and treatable entity. Muscle Nerve 59:658–664, 2019