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Revised upper limb module for spinal muscular atrophy: 12 month changes
Author(s) -
Pera Maria Carmela,
Coratti Giorgia,
Mazzone Elena S.,
Montes Jacqueline,
Scoto Mariacristina,
De Sanctis Roberto,
Main Marion,
Mayhew Anna,
Muni Lofra Robert,
Dunaway Young Sally,
Glanzman Allan M.,
Duong Tina,
Pasternak Amy,
Ramsey Danielle,
Darras Basil,
Day John W.,
Finkel Richard S.,
De Vivo Darryl C.,
Sormani Maria Pia,
Bovis Francesca,
Straub Volker,
Muntoni Francesco,
Pane Marika,
Mercuri Eugenio
Publication year - 2019
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.26419
Subject(s) - spinal muscular atrophy , sma* , medicine , upper limb , atrophy , physical medicine and rehabilitation , physical therapy , disease , mathematics , combinatorics
: The aim of the study was to assess 12 month changes in upper limb function in patients affected by spinal muscular atrophy type 2 and 3. Methods : Longitudinal 12 month data was collected in 114 patients, 60 type 2 and 54 type 3, using the Revised Upper Limb Module. Results : The 12 month changes ranged between ‐7 and 9 (mean: ‐0.41; SD: 2.93). The mean changes were not significantly different between the three spinal muscular atrophy groups (‐0.45 in type 2, ‐0.23 in non‐ambulant type 3 and ‐0.34 in ambulant type 3, p = 0.96) and the relationship between 12 month change and age classes was not significantly different among the three types of SMA patients. Discussion : Our results confirm that the Module explores a wide range of functional abilities and can be used in ambulant and non‐ambulant patients of different ages in conjunction with other functional scales. Muscle Nerve 59:426–430, 2019