Premium
Effects of treadmill training on microvascular remodeling in the rat after spinal cord injury
Author(s) -
Kissane Roger W. P.,
Wright Oliver,
Al'Joboori Yazi D.,
Marczak Paulina,
Ichiyama Ronaldo M.,
Egginton Stuart
Publication year - 2019
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.26379
Subject(s) - medicine , spinal cord , spinal cord injury , skeletal muscle , anatomy , glycolysis , stimulation , endocrinology , anesthesia , metabolism , psychiatry
ABSTRACT Introduction : The morphological characteristics of skeletal muscles innervated caudal to a spinal cord injury (SCI) undergo dramatic phenotypic and microvascular changes. Method : Female Sprague–Dawley rats received a severe contusion at thoracic level 9/10 and were randomly assigned to locomotor training, epidural stimulation, or a combination of the treatment groups (CB). Fiber type composition and capillary distribution were assessed in phenotypically distinct compartments of the tibialis anterior. Results : Spinal cord injury induced a shift in type II fiber phenotype from oxidative to glycolytic ( P < 0.05) as well as capillary loss within the oxidative core and glycolytic cortex; the CB treatment best maintained capillary supply within both compartments. Discussion : The angiogenic response of CB training improved capillary distribution across the muscle; capillary distribution became spatially more homogeneous and mean capillary supply area decreased, potentially improving oxygenation. There is an important role for weight‐bearing training in maintaining the oxidative phenotype of muscle after SCI. Muscle Nerve 59 :370–379, 2019