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Inflammation, Immunity, and amyotrophic lateral sclerosis: I. Etiology and pathology
Author(s) -
Lyon Miles S.,
WosiskiKuhn Marlena,
Gillespie Rachel,
Caress James,
Milligan Carol
Publication year - 2019
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.26289
Subject(s) - pathogenesis , amyotrophic lateral sclerosis , immune system , inflammation , medicine , disease , immunology , neuroimmunology , neuroinflammation , neuroscience , pathology , biology
Amyotrophic lateral sclerosis (ALS) is a severely debilitating disease characterized by progressive degeneration of motor neurons. Charcot first described ALS in 1869 1 ; however, its pathogenesis remains unknown, and effective treatments remain elusive. It is apparent that new paradigms must be investigated to understand the effectors of ALS, including inflammation, immune responses, and the body's response to stress and injury. Herein we discuss the potential role of the immune system in ALS pathogenesis and critically review evidence from patient and animal studies. Although immune system components may indeed play a role in ALS pathogenesis, studies implicating immune cells, antibodies, and cytokines in early disease pathology are limited. We propose more focused studies that examine the role of the immune system together with characterized pathogenesis to determine when, where, and if immune and inflammatory processes are critical to disease progression, and thus worthy targets of intervention. Muscle Nerve 59 :10–22, 2019