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Survival and mortality of adult‐onset myasthenia gravis in the population of Belgrade, Serbia
Author(s) -
Basta Ivana,
PekmezoviĆ Tatjana,
Peric Stojan,
NikoliĆ Ana,
RakoČeviĆStojanoviĆ Vidosava,
SteviĆ Zorica,
LavrniĆ Dragana
Publication year - 2018
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.26132
Subject(s) - medicine , myasthenia gravis , case fatality rate , mortality rate , population , demography , cohort , epidemiology , pediatrics , environmental health , sociology
ABSTRACT Introduction : The objective of this study was to estimate mortality and survival in a large cohort of myasthenia gravis (MG) patients from Belgrade, Serbia, during the period 1979–2008. Methods : Data for all patients with MG were collected from hospital records and the Belgrade MG Registry. Results : Within the 30‐year study period, death occurred in 107 (20%) of 562 patients with MG, with MG‐related fatality below 2%. The average MG mortality rate was 1.76 per 1,000,000 population (1.26/1,000,000 women, 2.45/1,000,000 men). A statistically significant increase was recorded for the average standardized mortality rate for all patients ( P < 0.01). The mean survival from disease onset was 34.3 ± 2.0 years. Significantly shorter survival was observed in men compared with women and in patients older than 50 years compared with younger ones ( P < 0.01). Discussion : We observed long survival and low frequency of MG‐related fatalities but increasing average standardized mortality rate, most notably in older men with MG. Muscle Nerve 58 : 708–712, 2018