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Therapeutic effect of microcurrent on calf muscle atrophy in immobilized rabbit
Author(s) -
Moon Yong Suk,
Kwon Dong Rak,
Lee YoonJin
Publication year - 2018
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.26110
Subject(s) - atrophy , muscle atrophy , medicine , immunohistochemistry , stimulation , gastrocnemius muscle , anatomy , urology , surgery , pathology , skeletal muscle
: Immobilization causes significant muscle loss. In this study we assessed the regenerative effect of microcurrent electrical stimulation (MES) on gastrocnemius muscle (GCM) atrophy induced by immobilization by cast (IC) in rabbits. Methods : Fifteen rabbits were divided into 3 groups: IC (group 1); IC and free re‐ambulation for 2 weeks after cast removal (CR) (group 2); and IC and MES for 2 weeks after CR (group 3). We evaluated clinical parameters (calf circumference, compound muscle action potential of tibial nerve, and thickness of GCM by ultrasound), histomorphometric data (muscle composition and cross‐sectional area), and immunohistochemistry. Results : Mean atrophic changes in clinical parameters in group 3 were significantly less than those in groups 1 and 2 ( P < 0.05). Histomophometric and immunohistochemical parameters in group 3 were significantly greater than those in groups 1 and 2, respectively ( P < 0.05). Discussion : MES prevents muscle atrophy and facilitates regeneration of muscle. Muscle Nerve 58 : 270–276, 2018