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Toenail mercury Levels are associated with amyotrophic lateral sclerosis risk
Author(s) -
Andrew Angeline S.,
Chen Celia Y.,
Caller Tracie A.,
Tandan Rup,
Henegan Patricia L.,
Jackson Brian P.,
Hall Brenda P.,
Bradley Walter G.,
Stommel Elijah W.
Publication year - 2018
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.26055
Subject(s) - methylmercury , mercury (programming language) , amyotrophic lateral sclerosis , quartile , odds ratio , confidence interval , medicine , population , biomarker , physiology , environmental chemistry , chemistry , environmental health , bioaccumulation , biochemistry , disease , computer science , programming language
: Mercury is a neurotoxic metal that is potentially a risk factor for amyotrophic lateral sclerosis (ALS). Consumption of methylmercury contaminated fish is the primary source of US population exposure to mercury. Methods : We used inductively coupled plasma mass spectrometry to measure levels of mercury in toenail samples from patients with ALS ( n = 46) and from controls ( n = 66) as a biomarker of mercury exposure. Results : Patients with ALS had higher toenail mercury levels (odds ratio 2.49, 95% confidence interval 1.18–5.80, P = 0.024) compared with controls, adjusted for age and sex. We also estimated the amount of mercury consumed from finfish and shellfish and found toenail mercury levels elevated overall among patients with ALS and controls in the top quartile for consumption ( P = 0.018). Discussion : Biomarker data show that ALS is associated with increased with mercury levels, which were related to estimated methylmercury intake via fish. Replication of these associations in additional populations is warranted. Muscle Nerve 58 : 36–41, 2018