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High frequency of MGUS in DSP
Author(s) -
Abraham Alon,
Barnett Carolina,
Katzberg Hans D.,
Lovblom Leif E.,
Perkins Bruce A.,
Bril Vera
Publication year - 2018
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.26054
Subject(s) - medicine , computer science
: Monoclonal gammopathy has been reported in several polyneuropathies . I n this study, we sought to explore the frequency and characteristics of monoclonal gammopathy in patients with diabetic sensorimotor polyneuropathy (DSP) . M ethods : P atients with type 1 and type 2 diabetes mellitus (DM 1, DM 2) and controls without diabetes were evaluated between N ovember 2008 and D ecember 2013 . Results : Fifty controls, 66 patients with DM 1 , and 106 patients with DM 2 were included, with average ages of 43 ± 18, 45 ± 17, and 65 ± 10 years, respectively; the frequency of monoclonal gammopathy was 0%, 8%, and 15%, respectively. I n patients with DSP, the frequency of monoclonal gammopathy increased to 14% in DM 1 and 21% in DM 2 ; the most common monoclonal proteins were immunoglobulin (Ig) M and IgG, respectively. Discussion : DSP might be associated with a high frequency of monoclonal gammopathy, with different characteristics in DM 1 and in DM 2. Muscle Nerve 57 : 1018–1021, 2018