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Non‐motor manifestations in ALS patients with tracheostomy and invasive ventilation
Author(s) -
Nakayama Yuki,
Shimizu Toshio,
Matsuda Chiharu,
Haraguchi Michiko,
Hayashi Kentaro,
Mochizuki Yoko,
Nagao Masahiro,
Kawata Akihiro,
Isozaki Eiji
Publication year - 2018
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.26004
Subject(s) - medicine , amyotrophic lateral sclerosis , mechanical ventilation , motor neurone disease , hyporeflexia , hypothermia , disease , stage (stratigraphy) , anesthesia , surgery , weakness , paleontology , biology
This study aimed to investigate non‐motor manifestations in amyotrophic lateral sclerosis (ALS) patients with tracheostomy and invasive ventilation (TIV) and their relevance to disease progression. Methods Sixty‐seven ALS patients with TIV were enrolled, and followed‐up prospectively. The patients were classified at the final evaluation into two subgroups according to the duration of TIV use or disease stage measured by communication impairment. We identified non‐motor manifestations and investigated their frequencies and differences across the stages. Results The non‐motor manifestations were macroglossia (22.4%), unstable blood pressure (38.8%), hypothermia (26.9%), dysuria (50.7%), and hyperglycemia (12.1%). These manifestations occurred significantly more frequently in patients with TIV ≥5 years than in patients with TIV <5 years, and more in patients with severe communication impairment than in those with preserved communication ability. Discussion Non‐motor manifestations are observed at a high rate in ALS patients with TIV, and are possibly related to disease progression. Muscle Nerve 57 : 735–741, 2018