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Prospective comparison of acute motor axonal neuropathy and acute inflammatory demyelinating polyradiculoneuropathy in 140 children with Guillain–Barré syndrome in India
Author(s) -
Kalita Jayantee,
Kumar Mritunjai,
Misra Usha K.
Publication year - 2018
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25992
Subject(s) - polyradiculoneuropathy , guillain barre syndrome , acute motor axonal neuropathy , medicine , polyradiculopathy , pediatrics , surgery
There have been few reports on subtypes of Guillain–Barré syndrome (GBS) in children. We compared clinical and laboratory findings of acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and acute motor axonal neuropathy (AMAN). Methods One hundred forty children with GBS were included. Based on nerve conduction study (NCS) findings, patients were subclassified as AIDP, AMAN, acute motor sensory axonal neuropathy (AMSAN), and equivocal. Results Clinically, 72.1% of patients had pure motor, 24.3% motor sensory, and 3.4% Miller Fisher syndrome. Based on NCS, 67.8% of patients had AIDP, 23.6% had AMAN, and 4.3% had AMSAN. By 3 months, 2.1% patients had died, 47.1% had complete recovery, and 24.3% had poor recovery (wheelchair‐bound). Children with AMAN had more frequent lower limb weakness ( P = 0.02) and a lower probability of complete recovery ( P = 0.01) at 3 months than children with AIDP (56% vs. 30%). Discussion AIDP is the most common GBS subtype in children. It is characterized by better recovery at 3 months when compared with AMAN. Muscle Nerve 57 : 761–765, 2018