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Extracorporeal shock wave treatment can selectively destroy end plates in neuromuscular junctions
Author(s) -
Kenmoku Tomonori,
Nemoto Noriko,
Iwakura Nahoko,
Ochiai Nobuyasu,
Uchida Kentaro,
Saisu Takashi,
Ohtori Seiji,
Nakagawa Koichi,
Sasho Takahisa,
Takaso Masashi
Publication year - 2018
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25754
Subject(s) - neuromuscular junction , neuromuscular transmission , compound muscle action potential , acetylcholine receptor , axon , anatomy , medicine , electrophysiology , biology , receptor , neuroscience
This study assesses the effect of radial extracorporeal shock wave (rESW) exposure on neuromuscular transmission and neuromuscular junction (NMJ) morphology. Methods We applied 2,000 rESWs at 0.18 mJ/mm 2 and a frequency of 15 H z to the right calf of male rats, measured the compound muscle action potential (CMAP), and examined NMJ morphology using electron microscopy. Left calf muscles were used as controls. Results rESW exposure significantly reduced CMAP amplitude without delayed latency in exposed muscles compared with controls. All rESW‐exposed muscles exhibited NMJs with irregular end plates. Mean interjunctional fold interval was significantly increased compared with controls. However, axon terminals and muscle fibers surrounding NMJs with irregular end plates were unchanged. Discussion This localized destruction of end plates may be caused by differences in acoustic impedance induced by the density of acetylcholine receptors. These results provide a possible mechanism for the effectiveness of rESW treatment for spasticity and dystonia. Muscle Nerve 57 : 466–472, 2018