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Longitudinal community walking activity in Duchenne muscular dystrophy
Author(s) -
Fowler Eileen G.,
Staudt Loretta A.,
Heberer Kent R.,
Sienko Susan E.,
Buckon Cathleen E.,
Bagley Anita M.,
Sussman Michael D.,
McDonald Craig M.
Publication year - 2018
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25743
Subject(s) - duchenne muscular dystrophy , medicine , physical medicine and rehabilitation , stride , muscular dystrophy , natural history , physical therapy , activity monitor , physical activity
Natural history studies for Duchenne muscular dystrophy (DMD) have not included measures of community ambulation. Methods Step activity (SA) monitors quantified community ambulation in 42 boys (ages 4–16 years) with DMD with serial enrollment up to 5 years by using a repeated‐measures mixed model. Additionally, data were compared with 10‐meter walk/run (10mWR) speed to determine validity and sensitivity. Results There were significant declines in average strides/day and percent strides at moderate, high and pediatric high rates as a function of age ( P < 0.05). Significant correlations for 10mWR versus high and low stride rates were found at baseline ( P < 0.05). SA outcomes were sensitive to change over 1 year, but the direction and parameter differed by age group (younger vs. older). Changes in strides/day and percentages of high frequency and low frequency strides correlated significantly with changes in 10mWR speed ( P < 0.05). Discussion Community ambulation data provide valid and sensitive real‐world measures that may inform clinical trials. Muscle Nerve 57 : 401–406, 2018