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Acute painful autoimmune neuropathy: A variant of Guillain‐Barré syndrome
Author(s) -
Yuki Nobuhiro,
Chan Amanda C.,
Wong Anna Hiu Yi,
Inoue Takayuki,
Yokai Masafumi,
Kurihara Takashi,
Devaux JérôMe J.,
WilderSmith Einar
Publication year - 2018
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25738
Subject(s) - guillain barre syndrome , medicine , hyporeflexia , antibody , polyradiculoneuropathy , immunology , anesthesia , gastroenterology , surgery , weakness
ABSTRACT Introduction We present a painful small‐fiber neuropathy variant of Guillain‐Barré syndrome characterized by antecedent infectious symptoms, hyporeflexia, and albuminocytologic dissociation. Methods Two patients received intravenous immunoglobulin, one corticosteroids. Results The patients subsequently improved. Immunoglobulin G (IgG) antibodies in their acute phase sera strongly bound to murine small nerve fibers, and the binding disappeared during the convalescent phase. Serum transfer to a murine nociceptive model induced transient alteration in thermal pain responses. Discussion Our case series suggest that an acute transient immune response can be directed against small nerve fibers, and that patients so affected can exhibit features of Guillain‐Barré syndrome. Muscle Nerve 57 : 320–324, 2018