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Recovery of rat muscle size but not function more than 1 year after a single botulinum toxin injection
Author(s) -
Ward Samuel R.,
Minamoto Viviane B.,
Suzuki Kentaro P.,
Hulst Jonah B.,
Bremner Shan N.,
Lieber Richard L.
Publication year - 2018
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25707
Subject(s) - neurotoxin , botulinum neurotoxin , botulinum toxin , clostridium botulinum , medicine , saline , skeletal muscle , muscle contraction , toxin , anesthesia , neuromuscular junction , anatomy , endocrinology , biology , biochemistry , neuroscience
Neurotoxin injection is used to treat a wide variety of neuromuscular disorders. The purpose of this study was to measure the functional and structural properties of botulinum toxin–injected adult rat skeletal muscle over nearly the entire lifespan. Methods Ten groups of animals were subjected to either neurotoxin injection [Botox, Type A (BT‐A); Allergan, Irvine, California] or saline solution injection. Neurotoxin‐injected animals ( n = 90) were analyzed at different time‐points: 1 week; 1 month; 3 months; 6 months; 12 months; or 18 months. Results In spite of the recovery of structural features, such as muscle mass and fiber area, dorsiflexion torque production remained significantly depressed by 25%, even at 12 months after neurotoxin injection. Discussion The data demonstrate that, after a single BT‐A injection, although gross muscle morphology recovered over a 12‐month time period, loss of contractile function did not recover. Muscle Nerve 57 : 435–441, 2018