Premium
Acute nutritional axonal neuropathy
Author(s) -
Hamel Johanna,
Logigian Eric L.
Publication year - 2018
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25702
Subject(s) - medicine , ataxia , polyneuropathy , vomiting , anorexia , sensory loss , weight loss , weakness , surgery , malnutrition , anesthesia , gastroenterology , pediatrics , psychiatry , obesity
: This study describes clinical, laboratory, and electrodiagnostic features of a severe acute axonal polyneuropathy common to patients with acute nutritional deficiency in the setting of alcoholism, bariatric surgery (BS), or anorexia. Methods : Retrospective analysis of clinical, electrodiagnostic, and laboratory data of patients with acute axonal neuropathy. Results : Thirteen patients were identified with a severe, painful, sensory or sensorimotor axonal polyneuropathy that developed over 2–12 weeks with sensory ataxia, areflexia, variable muscle weakness, poor nutritional status, and weight loss, often with prolonged vomiting and normal cerebrospinal fluid protein. Vitamin B6 was low in half and thiamine was low in all patients when obtained before supplementation. Patients improved with weight gain and vitamin supplementation, with motor greater than sensory recovery. Discussion : We suggest that acute or subacute axonal neuropathy in patients with weight loss or vomiting associated with alcohol abuse, BS, or dietary deficiency is one syndrome, caused by micronutrient deficiencies. Muscle Nerve 57 : 33–39, 2018