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Serum brain‐derived neurotrophic factor and interleukin‐6 response to high‐volume mechanically demanding exercise
Author(s) -
Verbickas Vaidas,
Kamandulis Sigitas,
Snieckus Audrius,
Venckunas Tomas,
Baranauskiene Neringa,
Brazaitis Marius,
Satkunskiene Danguole,
Unikauskas Alvydas,
Skurvydas Albertas
Publication year - 2018
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25687
Subject(s) - medicine , brain derived neurotrophic factor , endocrinology , neurotrophic factors , stimulation , peripheral , interleukin , interleukin 1β , physical exercise , cytokine , receptor
ABSTRACT Introduction: The aim of this study was to follow circulating brain‐derived neurotrophic factor (BDNF) and interleukin‐6 (IL‐6) levels in response to severe muscle‐damaging exercise. Methods: Young healthy men ( N = 10) performed a bout of mechanically demanding stretch–shortening cycle exercise consisting of 200 drop jumps. Voluntary and electrically induced knee extension torque, serum BDNF levels, and IL‐6 levels were measured before and for up to 7 days after exercise. Results: Muscle force decreased by up to 40% and did not recover by 24 hours after exercise. Serum BDNF was decreased 1 hour and 24 hours after exercise, whereas IL‐6 increased immediately and 1 hour after but recovered to baseline by 24 hours after exercise. IL‐6 and 100‐Hz stimulation torque were correlated ( r = −0.64, P < 0.05) 24 hours after exercise. Discussion: In response to acute, severe muscle‐damaging exercise, serum BDNF levels decrease, whereas IL‐6 levels increase and are associated with peripheral fatigue. Muscle Nerve 57 : E46–E51, 2018