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Peripheral nerve atrophy together with higher cerebrospinal fluid progranulin indicate axonal damage in amyotrophic lateral sclerosis
Author(s) -
Schreiber Stefanie,
DebskaVielhaber Grazyna,
Abdulla Susanne,
Machts Judith,
Schreiber Frank,
Kropf Siegfried,
KÖrtvelyessy Peter,
KÖrner Sonja,
Kollewe Katja,
Petri Susanne,
Dengler Reinhard,
Kunz Wolfram S.,
Nestor Peter J.,
Vielhaber Stefan
Publication year - 2018
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25682
Subject(s) - amyotrophic lateral sclerosis , cerebrospinal fluid , medicine , atrophy , peripheral , peripheral neuropathy , pathology , multiple sclerosis , nerve growth factor , endocrinology , immunology , diabetes mellitus , receptor , disease
We aimed to investigate whether sonographic peripheral cross‐sectional nerve area (CSA) and progranulin (PGRN), a neuritic growth factor, are related to each other and whether they interact to predict clinical and paraclinical measures in amyotrophic lateral sclerosis (ALS). Methods We included 55 ALS patients who had forearm median and ulnar nerve CSA, cerebrospinal fluid (CSF) PGRN, and serum PGRN measures available. CSF PGRN was normalized against the CSF / serum albumin ratio (Q alb ). Using age, sex, height, and weight adjusted general linear models, we examined CSA × CSF PGRN interaction effects on various measures. Results There was a medium‐effect size inverse relationship between CSA and CSF PGRN, but not between CSA and serum PGRN. Lower CSA values together with higher CSF PGRN levels were linked to smaller motor amplitudes. Discussion In ALS, the constellation of peripheral nerve atrophy together with higher CSF PGRN levels indicates pronounced axonal damage. Muscle Nerve 57 : 273–278, 2018