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Assessment of the synergic effect of immunomodulation on nerve repair using multiparametric magnetic resonance imaging
Author(s) -
Zheng ChuShan,
Zhang Xiang,
Chen YueYao,
Zhang Fang,
Duan XiaoHui,
Chen MeiWei,
Lu LieJing,
Shen Jun
Publication year - 2018
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25674
Subject(s) - regeneration (biology) , sciatic nerve , microinjection , medicine , magnetic resonance imaging , lipopolysaccharide , nerve injury , pathology , anesthesia , radiology , microbiology and biotechnology , biology
ABSTRACT Introduction The immune system plays a pivotal role in nerve injury. The aim of this study was to determine the role of multiparametric magnetic resonance imaging (MRI) in evaluation of the synergic effect of immunomodulation on nerve regeneration in neurotmesis. Methods Rats with sciatic nerve neurotmesis and surgical repair underwent serial multiparametric MR examinations over an 8‐week period after subepineurial microinjection of lipopolysaccharide (LPS) and subsequent subcutaneous injection of FK506 or subepineurial microinjection of LPS or phosphate‐buffered saline (PBS) alone. Results Nerves treated with immunomodulation showed more prominent regeneration than those treated with LPS or PBS alone and more rapid restoration toward normal T2, fractional anisotropy (FA), and radial diffusivity (RD) values than nerves injected with LPS or PBS. Discussion Nerves treated with immunomodulation exert synergic beneficial effects on nerve regeneration that can be predicted by T2 measurements and FA and RD values. Muscle Nerve 57 : E38–E45, 2018