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Ultrastructural changes in human masseter muscles after botulinum neurotoxin a injection
Author(s) -
Ma Fushun,
Zhai Zhaohui,
Zhu Shunwen,
Tang Shengjian
Publication year - 2018
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25609
Subject(s) - masseter muscle , ultrastructure , anatomy , sarcomere , organelle , botulinum toxin , pathology , medicine , chemistry , biology , myocyte , microbiology and biotechnology , anesthesia
Botulinum neurotoxin A (BoNTA) has long been used as a therapeutic agent and has been widely accepted as a cosmetic agent in recent years. It can inhibit function and induce structural changes in skeletal muscle. Methods Specimens of fresh dissected human masseter muscle were used to observe the ultrastructural changes that occurred at 6 and 12 months following BoNTA injection. Results The findings observed were muscle fiber distortion, sarcomere shortening, mitochondrial vacuolar degeneration, glycogen accumulation, and H and M band disruption in the triad of tubules. At 12 months after injection, there was still evidence of degenerative changes in muscle ultrastructure, whereas most organelles exhibited a normal structure. Discussion Profound ultrastructural and organelle disfiguring changes were observed after BoNTA injection into human masseter muscle. Most changes were transient, however, and were resolved by 12 months after injection. Muscle Nerve 57 : 96–99, 2018