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Physical function and muscle strength in sporadic inclusion body myositis
Author(s) -
Jørgensen Anders N.,
Aagaard Per,
Nielsen Jakob L.,
Christiansen Mette,
Hvid Lars G.,
Frandsen Ulrik,
Diederichsen Louise P.
Publication year - 2017
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25603
Subject(s) - muscle strength , muscle weakness , physical medicine and rehabilitation , gait , medicine , physical therapy , psychology
In this study, self‐reported physical function, functional capacity, and isolated muscle function were investigated in sporadic inclusion body myositis (sIBM) patients. Methods: The 36‐item Short Form (SF‐36) Health Survey and 2‐min walk test (2MWT), timed up & go test (TUG), and 30‐s chair stand performance were evaluated. In addition, patients were tested for knee extensor muscle strength (isokinetic dynamometer) and leg extension power (Nottingham power rig). Results: TUG performance was the strongest predictor of self‐reported physical function ( r 2 = 0.56, P < 0.05). Knee extension strength and between‐limb strength asymmetry were the strongest multi‐regression indicators of TUG performance ( r 2 = 0.51, P < 0.05). Strength asymmetry showed the strongest single‐factor (negative) association with 2MWT performance ( r 2 = 0.49, P < 0.05). Discussion: TUG assessment appears to sensitively predict self‐perceived physical function in sIBM patients. Notably, between‐limb asymmetry in lower limb muscle strength had a substantial negative impact on motor tasks involving gait function. Muscle Nerve 56 : E50–E58, 2017