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Effects of exercise‐induced apelin levels on skeletal muscle and their capillarization in type 2 diabetic rats
Author(s) -
Son Jun Seok,
Kim HeeJae,
Son Yeri,
Lee Hojun,
Chae Song Ah,
Seong Je Kyung,
Song Wook
Publication year - 2017
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25596
Subject(s) - apelin , medicine , endocrinology , skeletal muscle , soleus muscle , insulin resistance , myokine , physical exercise , angiogenesis , homeostasis , insulin , receptor
Exercise‐induced apelin as a myokine is believed to play a role in the improvement of type 2 diabetes mellitus (T2DM) and capillarization. In this study, we evaluated the association between exercise‐induced apelin and muscle capillarization. Methods Zucker rats underwent a treadmill exercise program. Body composition, muscle strength, muscle size, muscle capillarization, and insulin resistance (homeostatic model assessment [HOMA‐IR]) were measured. Apelin levels of skeletal muscle and plasma were then analyzed. Results Exercise improved body composition ( P < 0.05), HOMA‐IR ( P < 0.05), and grip strength ( P < 0.001). In the soleus, the fiber size of T2DM was decreased ( P < 0.001), but it increased in fiber size and capillarization after exercise ( P < 0.001) occurred. We identified an increase in plasma apelin ( P < 0.05) and a decrease in soleus apelin ( P < 0.01), as well as an association between soleus apelin and angiogenesis ( P < 0.01). Discussion A role for exercise‐induced apelin in improving metabolism indicates the possibility of a new drug target for the treatment of metabolic diseases and repairing skeletal muscle damage. Muscle Nerve 56 : 1155–1163, 2017