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Fixed dynamometry is more sensitive than vital capacity or ALS rating scale
Author(s) -
Andres Patricia L.,
Allred Margaret Peggy,
Stephens Helen E.,
Proffitt Bunnell Mary,
Siener Catherine,
Macklin Eric A.,
Haines Travis,
English Robert A.,
Fetterman Katherine A.,
Kasarskis Edward J.,
Florence Julaine,
Simmons Zachary,
Cudkowicz Merit E.
Publication year - 2017
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25586
Subject(s) - isometric exercise , amyotrophic lateral sclerosis , rating scale , physical medicine and rehabilitation , physical therapy , medicine , sample size determination , psychology , mathematics , statistics , disease , developmental psychology
ABSTRACT Introduction : Improved outcome measures are essential to efficiently screen the growing number of potential amyotrophic lateral sclerosis (ALS) therapies. Methods : This longitudinal study of 100 (70 male) participants with ALS compared Accurate Test of Limb Isometric Strength (ATLIS), using a fixed, wireless load cell, with ALS Functional Rating Scale‐Revised (ALSFRS‐R) and vital capacity (VC). Results : Participants enrolled at 5 U.S. sites. Data were analyzed from 66 participants with complete ATLIS, ALSFRS‐R, and VC data over at least 3 visits. Change in ATLIS was less variable both within‐ and among‐person than change in ALSFRS‐R or VC. Additionally, participants who had normal ALSFRS‐R arm and leg function averaged 12 to 32% below expected strength values measured by ATLIS. Conclusions : ATLIS was more sensitive to change than ALSFRS‐R or VC and could decrease sample size requirements by approximately one‐third. The ability of ATLIS to detect prefunctional change has potential value in early trials. Muscle Nerve 56 : 710–715, 2017