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Non‐invasive assessment of muscle injury in healthy and dystrophic animals with electrical impedance myography
Author(s) -
Sanchez Benjamin,
Iyer Shama R.,
Li Jia,
Kapur Kush,
Xu Su,
Rutkove Seward B.,
Lovering Richard M.
Publication year - 2017
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25559
Subject(s) - electrical impedance myography , eccentric , medicine , muscle contraction , duchenne muscular dystrophy , anatomy , physics , quantum mechanics , vasodilation
Dystrophic muscle is particularly susceptible to eccentric contraction–induced injury. We tested the hypothesis that electrical impedance myography (EIM) can detect injury induced by maximal‐force lengthening contractions. Methods We induced injury in the quadriceps of wild‐type (WT) and dystrophic ( mdx ) mice with eccentric contractions using an established model. Results mdx quadriceps had significantly greater losses in peak twitch and tetany compared with losses in WT quadriceps. Injured muscle showed a significant increase in EIM characteristic frequency in both WT (177 ± 7.7%) and mdx (167 ± 7.8%) quadriceps. EIM also revealed decreased extracellular resistance for both WT and mdx quadriceps after injury. Discussion Our results show overall agreement between muscle function and EIM measurements of injured muscle, indicating that EIM is a viable tool to assess injury in dystrophic muscle. Muscle Nerve 56 : E85–E94, 2017