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Cardiometabolic health and risk of amyotrophic lateral sclerosis
Author(s) -
Timmins Hannah C.,
Saw Wilfred,
Cheah Benjamin C.,
Lin Cindy S.Y.,
Vucic Steve,
Ahmed Rebekah M.,
Kiernan Matthew C.,
Park Susanna B.
Publication year - 2017
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25547
Subject(s) - medicine , amyotrophic lateral sclerosis , dyslipidemia , cohort , body mass index , population , cardiology , blood pressure , cohort study , physical therapy , obesity , disease , environmental health
Patients diagnosed with amyotrophic lateral sclerosis (ALS) generally have a limited medical history and a normal body mass index, raising the possibility of a premorbid ALS phenotype. Methods The prevalence of cardiometabolic factors was analyzed in 58 ALS patients via comprehensive cardiovascular assessments and compared with Australian population norms. Results ALS patients had good cardiac fitness and no reported cardiovascular events. Average blood pressure, heart rate, PR interval, and corrected QT interval were in the normal range. There were significantly fewer obese women in the ALS cohort (13.6%, P < 0.05) and more men with a normal body mass index than in the general population (47.2%, P < 0.001). The percentage of individuals who had never smoked was greater for the ALS cohort (55.8%, P ≤ 0.001), and the prevalence of dyslipidemia was lower (38.7%) compared with the general population (74.4%, P < 0.001). Conclusion ALS patients had good cardiometabolic health, with evidence of a reduced vascular risk profile. Muscle Nerve 56 : 721–725, 2017