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Validation of the italian version of the 15‐item Myasthenia Gravis Quality‐of‐Life questionnaire
Author(s) -
Raggi Alberto,
Leonardi Matilde,
Ayadi Roberta,
Antozzi Carlo,
Maggi Lorenzo,
Baggi Fulvio,
Mantegazza Renato
Publication year - 2017
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25545
Subject(s) - myasthenia gravis , wilcoxon signed rank test , medicine , cronbach's alpha , mann–whitney u test , rank correlation , quality of life (healthcare) , spearman's rank correlation coefficient , physical therapy , test (biology) , rating scale , correlation , psychology , psychometrics , clinical psychology , statistics , developmental psychology , paleontology , mathematics , nursing , biology , geometry
In this study we assess the Italian version of the 15‐item Myasthenia Gravis Quality‐of‐Life questionnaire (MG‐QOL15). Methods The validation protocol included the MG‐QOL15, the 36‐item Short Form (SF‐36), the Besta Neurological Institute Rating Scale for Myasthenia Gravis, and the MG‐Composite. We used the Cronbach α to test reliability, the Spearman correlation to test short‐term test–retest, the Kruskal–Wallis test to assess differences in MG‐QOL15 between patients with different disease severity, and the Wilcoxon signed‐rank test to assess sensitivity to change. Results Seventy‐two patients were enrolled in the study. The mean MG‐QOL15 score was 15.2 ± 12.2, with α = 0.93 and test–retest correlation = 0.93. Compared with the SF‐36, the MG‐QOL15 was superior in differentiating patients with different MG types ( P  = 0.041) and severity ( P  = 0.004), showed higher sensitivity to change ( P  = 0.003 for improved and P  = 0.024 for worsened patients), and had higher correlations with the MG‐Composite (rho = 0.367 vs. –0.213 and –0.154). Conclusion The Italian version of the MG‐QOL15 is valid, reliable, stable, and sensitive to changes. Muscle Nerve 56 : 716–720, 2017

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