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Characterization of the nociceptive effect of carrageenan: Masseter versus gastrocnemius
Author(s) -
Bagüés Ana,
MartínFontelles M. Isabel,
EstebanHernández Jesús,
SánchezRobles Eva M.
Publication year - 2017
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25538
Subject(s) - masseter muscle , nociception , gastrocnemius muscle , medicine , carrageenan , hyperalgesia , pathophysiology , anesthesia , nociceptor , anatomy , pathology , skeletal muscle , receptor , pharmacology
To better understand the pathophysiology of chronic muscle pain, there are multiple animal models that mimic different acute/chronic pain conditions, such as carrageenan injection. Our previous studies demonstrated differences between muscles of different innervation in acute pain. In this study we characterized the effect of carrageenan in 2 muscles: masseter (trigeminal innervation) and gastrocnemius (spinal innervation). Methods Carrageenan (3%, 6%, and 9%) was injected into the masseter and gastrocnemius of rats. Mechanical, heat, and chemical nociceptive thresholds were measured for 14 days. Results Carrageenan did not induce mechanical allodynia or thermal hypersensitivity in either muscle. Instead, it induced a short‐lasting mechanical hyperalgesia, greater in the masseter than in the gastrocnemius. Conclusion Carrageenan injected into the masseter and gastrocnemius induces a short‐lasting hyperalgesia. These results could indicate a higher susceptibility of orofacial muscles to this type of insult and, consequently, a difference between trigeminal and spinal innervation. Muscle Nerve 56 : 804–813, 2017