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Cramp‐fasciculation syndrome associated with monofocal motor neuropathy
Author(s) -
Dubuisson Nicolas J.,
Pesch Vincent,
Bergh Peter Y.K.
Publication year - 2017
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25528
Subject(s) - fasciculation , medicine , multifocal motor neuropathy , electromyography , motor nerve , anesthesia , surgery , physical medicine and rehabilitation , anatomy , mismatch negativity , electroencephalography , psychiatry
Cramp‐fasciculation syndrome is a peripheral nerve hyperexcitability disorder, which could be caused by inflammatory neuropathy. Case Report We describe a 51‐year‐old woman who presented with a 4‐ to 5‐year history of fasciculations and painful cramping of the right thenar eminence. Results Electrophysiological studies showed motor conduction block in the right median nerve between the axilla and the elbow with fasciculation potentials and cramp discharges on electromyography in the right abductor pollicis brevis muscle. High titers of serum anti‐GM1 immunoglobulin M antibodies were detected. Conclusions Monofocal motor neuropathy of the right median nerve was diagnosed. Intravenous immunoglobulin treatment led to significant improvement of symptoms and signs. Although fasciculations and cramps have been reported in multifocal motor neuropathy and are considered supporting criteria for the diagnosis, the occurrence of cramp‐fasciculation syndrome as the presenting feature and predominant manifestation in monofocal motor neuropathy, a variant of multifocal motor neuropathy, is unique. Muscle Nerve 56 : 828–832, 2017