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Electrophysiological and neuromuscular stability of persons with chronic inflammatory demyelinating polyneuropathy
Author(s) -
Gilmore Kevin J.,
Allen Matti D.,
Doherty Timothy J.,
Kimpinski Kurt,
Rice Charles L.
Publication year - 2017
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25516
Subject(s) - electromyography , chronic inflammatory demyelinating polyneuropathy , motor unit , compound muscle action potential , neuromuscular transmission , medicine , concentric , physical medicine and rehabilitation , electrophysiology , weakness , neuromuscular disease , polyneuropathy , spinal muscular atrophy , isometric exercise , peripheral neuropathy , anatomy , endocrinology , mathematics , geometry , disease , antibody , immunology , diabetes mellitus
We assessed motor unit (MU) properties and neuromuscular stability in the tibialis anterior (TA) of chronic inflammatory demyelinating polyneuropathy (CIDP) patients using decomposition‐based quantitative electromyography. Methods Dorsiflexion strength was assessed, and surface and concentric needle electromyography were sampled from the TA. Estimates of MU numbers were derived using decomposition‐based quantitative electromyography and spike‐triggered averaging. Neuromuscular transmission stability was assessed from concentric needle‐detected MU potentials. Results CIDP patients had 43% lower compound muscle action potential amplitude than controls, and despite near‐maximum voluntary activation, were 37% weaker. CIDP had 27% fewer functioning MUs in the TA, and had 90% and 44% higher jiggle and jitter values, respectively compared with controls. Conclusions CIDP had lower strength and compound muscle action potential values, moderately fewer numbers of MUs, and significant neuromuscular instability compared with controls. Thus, in addition to muscle atrophy, voluntary weakness is also due to limitations of peripheral neural transmission consistent with demyelination. Muscle Nerve 56 : 413–420, 2017