Premium
High‐resolution manometry in patients with idiopathic inflammatory myopathy: Elevated prevalence of esophageal involvement and differences according to autoantibody status and clinical subset
Author(s) -
CasalDominguez Maria,
PinalFernandez Iago,
Mego Marianela,
Accarino Anna,
Jubany Lluis,
Azpiroz Fernando,
SelvaO'callaghan Albert
Publication year - 2017
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25507
Subject(s) - medicine , polymyositis , gastroenterology , dermatomyositis , esophagus , myositis , antisynthetase syndrome , high resolution manometry , autoantibody , myopathy , serology , interstitial lung disease , immunology , achalasia , antibody , lung
In this study we assessed high‐resolution manometry (HRM) findings in patients with dermatomyositis and polymyositis. Methods From 2008 to 2015, we performed a cross‐sectional study of myositis patients. A survey of esophageal symptoms and HRM data were analyzed and compared among different clinical and serologic groups. Results Twenty‐four (45%) of the 53 patients included in the study had manometric involvement that was not correlated with any esophageal symptom ( P = 0.8). Failed waves (34% vs. 0%, P = 0.004) and decreased upper esophageal sphincter pressure (50 vs. 70 mm Hg, P = 0.03) were more common in polymyositis than in dermatomyositis patients. Jackhammer esophagus was more common in anti–TIF1‐γ patients (30% vs. 9%, P = 0.04), and lower esophageal sphincter involvement (47% vs. 25%, P = 0.03) was more prevalent in patients with the antisynthetase syndrome. Conclusions Esophageal involvement is common in myositis patients, but it correlates poorly with esophageal symptoms. Specific clinical and serologic groups have different manometric features. Muscle Nerve 56 : 386–392, 2017