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Physical exercise in myasthenia gravis is safe and improves neuromuscular parameters and physical performance‐based measures: A pilot study
Author(s) -
Westerberg Elisabet,
Molin Carl Johan,
Lindblad Ida,
Emtner Margareta,
Punga Anna Rostedt
Publication year - 2017
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25493
Subject(s) - myasthenia gravis , neuromuscular disease , biceps , medicine , repetitive nerve stimulation , physical therapy , physical medicine and rehabilitation , compound muscle action potential , physical exercise , disease , electrophysiology
ABSTRACT Introduction : Due to the shortage of exercise‐related research in Myasthenia Gravis (MG), there are no consensus guidelines on physical exercise for MG patients. Methods : In this prospective pilot study, 10 MG patients with mild disease performed supervised aerobic and resistance training twice weekly for 12 weeks. The Myasthenia Gravis Composite (MGC) score, compound motor action potential (CMAP), repetitive nerve stimulation, muscle force, physical performance‐based measures, serum levels of interleukin‐6, muscle enzymes, and immuno‐microRNAs miR‐150‐5p and miR‐21‐5p were assessed before and after the training period. Results : Physical exercise was well tolerated, and the MGC score was unchanged. Muscle resistance weights and CMAP amplitudes increased for biceps brachii and rectus femoris muscles, and physical performance‐based measures improved. Muscle enzymes remained normal, whereas disease‐specific microRNAs miR‐150‐5p and miR‐21‐5p were reduced after the training period. Conclusions : We propose that general recommendations regarding physical exercise can be applied safely to well‐regulated MG patients. Muscle Nerve 56 : 207–214, 2017