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Activity limitations in myasthenia gravis and relation to clinical variables
Author(s) -
Meel Robert H.P.,
Lipka Alexander F.,
Lende Marije,
Zwet Erik W.,
Tannemaat Martijn R.,
Verschuuren Jan J.G.M.
Publication year - 2017
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25463
Subject(s) - myasthenia gravis , medicine , muscle weakness , neuromuscular disease , physical therapy , disease
It is unknown how fluctuations in muscle weakness affect activity limitations in myasthenia gravis patients and how the severity of these limitations compares with published data on other neuromuscular disorders (NMD). Methods In this study we analyzed ACTIVLIM (acronym of “ACTIVity LIMitations”) and quantitative myasthenia gravis (QMG) scores. We assessed the impact of QMG and other clinical variables on ACTIVLIM, using B coefficients. Results The mean ACTIVLIM score in 118 MG patients was 3.3. There was a correlation between QMG and ACTIVLIM (B coefficient = −0.206, P < 0.001) and between changes in both scores (B coefficient = −0.175, P = 0.002). Men and patients without another autoimmune disease had a better ACTIVLIM score (B coefficient = 0.785, P = 0.015 and B coefficient = 0.998, P = 0.008, respectively). Conclusions The ACTIVLIM score in MG is higher than in other NMD. Fluctuations in QMG correlated significantly with changes in ACTIVLIM. Muscle Nerve 56 : 64–70, 2017.