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Comparative study of peripheral nerve Mri and ultrasound in multifocal motor neuropathy and amyotrophic lateral sclerosis
Author(s) -
Jongbloed Bas A.,
Haakma Wieke,
Goedee H. Stephan,
Bos Jeroen W.,
Bos Clemens,
Hendrikse Jeroen,
Berg Leonard H.,
Der Pol W. Ludo
Publication year - 2016
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25391
Subject(s) - multifocal motor neuropathy , medicine , mismatch negativity , amyotrophic lateral sclerosis , magnetic resonance neurography , ulnar nerve , median nerve , peripheral , magnetic resonance imaging , forearm , carpal tunnel syndrome , peripheral neuropathy , anatomy , radiology , pathology , electroencephalography , disease , elbow , psychiatry , diabetes mellitus , endocrinology
Differentiating multifocal motor neuropathy (MMN) from amyotrophic lateral sclerosis (ALS) is important, as MMN is a difficult, but treatable disorder. Methods: We studied peripheral nerve imaging techniques in differentiating MMN from ALS by measuring the cross‐sectional area (CSA) of the median and ulnar nerves in the forearms using high resolution ultrasound (HRUS) and MRI. Results: HRUS CSA values of the median nerve in the forearm (P = 0.002) and the ulnar nerve distal to the sulcus (P = 0.009) were significantly enlarged in patients with MMN. There was a positive correlation between CSA as measured with HRUS and MRI (Spearman rho 0.60; P < 0.001). Conclusions: Peripheral nerve imaging is a potentially powerful technique to distinguish MMN from ALS. Muscle Nerve , 2016 Muscle Nerve 54 : 1133–1135, 2016