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Abnormal distribution of GABA A receptors in brain of duchenne muscular dystrophy patients
Author(s) -
Suzuki Yuji,
Higuchi Shinya,
Aida Izumi,
Nakajima Takashi,
Nakada Tsutomu
Publication year - 2017
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25383
Subject(s) - duchenne muscular dystrophy , medicine , muscular dystrophy , neuroscience , biology
In this study we sought to: (1) determine the distribution of GABA A receptors (GABA A ‐Rs) in the brain of Duchenne muscular dystrophy (DMD) patients; and (2) ascertain if the distribution pattern correlates with cognitive dysfunction. Methods: Fourteen DMD patients [young adult ( n = 7, 18–25 years old) and older adult ( n = 7, 30–37 years old) groups] and 16 age‐matched normal volunteers participated. GABA A ‐R distribution was assessed using 123 I‐IMZ‐SPECT. Neuropsychological assessments were performed using 3 different test batteries, the WAIS‐III, WMS‐R, and Wisconsin Card Sorting Test (WCST). Results: All DMD patients showed significant decline in 123 I‐IMZ uptake in the prefrontal cortex ( P < 0.05). Although no differences were detected in the WAIS‐III and WMS‐R, the WCST scores of DMD patients (2.8 ± 1.9) were significantly lower ( P < 0.01) than those of normal volunteers (5.4 ± 0.7). Both abnormalities were more pronounced in older adult patients. Conclusion: The findings demonstrate that DMD is accompanied by a reduction in the prefrontal cortex distribution of GABA A ‐Rs. Muscle Nerve 55 : 591–595, 2017