Premium
Differential weakness of finger extensor muscles: A clinical pattern of multifocal motor neuropathy
Author(s) -
Ivanovski Trajche,
Miralles Francesc
Publication year - 2017
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25247
Subject(s) - multifocal motor neuropathy , weakness , medicine , differential diagnosis , muscle weakness , proximal muscle weakness , mismatch negativity , electromyography , physical medicine and rehabilitation , pathology , surgery , muscle biopsy , biopsy , electroencephalography , psychiatry
: Several studies have suggested that differential weakness in muscles supplied by the same motor nerve supports the diagnosis of multifocal motor neuropathy (MMN). Methods : We describe the clinical, electrophysiological, neuroimaging, and laboratory findings of patients with a lower motor syndrome whose clinical presentation included differential finger extension weakness that we have seen in our neuromuscular clinic. Results : We identified 3 patients with hand weakness and 1 patient with asymmetric weakness of the upper extremity. Conduction blocks (CBs) were identified in 1 patient. Anti‐GM1 immunoglobulin M antibodies were detected in 2 of the 3 patients tested. Only 1 patient responded to intravenous immunoglobulin (IVIg). Rituximab was administered in another patient, but we did not detect a response. Conclusions : We suggest that differential finger extension weakness is a feature that may be seen in MMN, even in the absence of CB or response to IVIg. Muscle Nerve 55 : 433–437, 2017